一项老鼠研究表明，父亲的饮食可能会在儿子怀孕之前就影响他们的焦虑和女儿的代谢健康。 发表在《自然通讯》上的一项新研究发现，雄性小鼠饮食中的大量营养素平衡会影响儿子的焦虑行为水平和女儿的代谢健康。 这项研究为理解饮食的影响如何通过父亲的精子代代相传提供了一个步骤。 它最终可以为准爸爸提供饮食指南，目的是降低下一代患代谢性疾病和情绪障碍的风险。 父母喜欢相信他们可以塑造孩子的兴趣和行为，并取得喜忧参半的成功。 但是，一个国际研究小组的一项新研究证实了老鼠的情况，因为父亲通过自己的饮食来塑造孩子的健康。 科学家们已经发现，老鼠父亲的饮食不仅会影响他自己的生殖健康，还会影响他的后代。 喂食过量或不足的雄性老鼠会影响其后代的新陈代谢和行为，以及患癌症的风险。 人们较少了解的是，根据雄性小鼠在受孕前的饮食类型和组成，是否对后代的健康有不同类型的影响。 这是国际壁虎联合会科学家与哥本哈根、悉尼和芝加哥的主要研究人员进行研究的起点。 在悉尼大学位于澳大利亚的charlesperkins中心，研究人员给雄性老鼠喂食蛋白质、脂肪和碳水化合物比例不同的10种饮食中的一种，然后让它们与标准饮食饲养的雌性交配。 然后对这些幼崽的行为和生理进行了研究。 与热量一样重要的饮食成分科学家发现，喂食低蛋白和高碳水化合物饮食的雄性小鼠更有可能生下焦虑程度更高的雄性后代，这是通过在迷宫安全区呆的时间来衡量的。 他们还发现，喂食高脂肪饮食的雄性小鼠更有可能生下体脂水平和代谢性疾病标志物较高的女儿。 “我们的研究表明，受孕前的饮食类型可以规划下一代的特定特征，”来自哥本哈根大学和尼斯蔚蓝海岸大学的壁虎联盟的共同高级作者兼领导者romain barrès教授说。 “通过滴定父亲饮食中蛋白质、脂肪和碳水化合物的混合物，我们可以影响他儿子和女儿的健康和行为，这是非同寻常的。 悉尼大学charlesperkins中心的学术主任、资深作者之一stephensimpson教授说。 研究小组还观察到，低蛋白饮食的男性总体上也吃得更多。 然而，由于这项研究的设计，他们可以确定雄性饮食中的热量和宏量营养成分都会影响其后代的健康。 “我们的研究表明，不仅仅是吃得太多或太少，饮食的组成也会对未来的孩子产生影响，”romain barrès教授说。 这项工作是在小鼠身上进行的，为该团队研究相关的分子机制开辟了道路。 这项老鼠研究是壁虎联盟内一系列更广泛研究的一部分，涉及合作机构的人类和其他哺乳动物。 romain barrès教授说：“我们认为，我们的研究是朝着为准爸爸制定饮食指南迈出的一步，最终目标是降低下一代患代谢性疾病和情绪障碍的风险。”。 声明：所有研究程序均由悉尼大学动物伦理委员会审查和批准（项目编号：2019/1610）。 这项工作得到了新诺氏盘基金会（nnf18oc0033754）向配子表观遗传学联盟（gecko）提供的挑战项目资助。 新诺基金会基础代谢研究中心是哥本哈根大学的一个独立研究中心，部分资金来自新诺基金（nnf18cc0034900）的无限制捐款。 这项工作得到了法国政府（国家研究机构，anr）通过“未来投资”计划labelx signalfe anr-11-labx-0028-01和idex ucajedi anr-15-idex-01的支持。 这项工作得到了法国政府（国家研究机构，anr）通过“未来投资”计划labelx signalfe anr-11-labx-0028-01和idex ucajedi anr-15-idex-01的支持。
a mice study suggests a fathers diet may shape the anxiety of his sons and the metabolic health of his daughters before they are even conceived.new research, published in nature communications, finds that the macronutrient balance in the diet of male mice affects the level of anxiety-like behaviour of sons and the metabolic health of daughters.the research provides a step towards understanding how the effect of diet can transmit from one generation to the next via a father’s sperm. it could ultimately inform dietary guidelines for fathers-to-be, with the goal of lowering the risk of metabolic disease and mood disorders in the next generation.parents like to believe they can shape the interests and behaviour of their children, with mixed success. but a new study from an international team of researchers confirms this is the case for mice, with father’s shaping their children’s health through their own diet.scientists have already discovered that a mouse father’s diet can have an impact not only on his own reproductive health but on that of his offspring. over- or under-feeding male mice can affect their offspring’s metabolism and behaviour, as well as their risk of cancer). what is less understood is whether there are diverse types of health impacts on the health of offspring, depending on the type and composition of the diet of male mice before conception.this was the starting point for the research by scientists in the international gecko consortium, with lead investigators in copenhagen, sydney, and chicago.at the university of sydney’s charles perkins centre in australia researchers fed male mice one of ten diets differing in the proportions of protein, fats, and carbohydrates, then allowed them to mate with females reared on standard diet. the behaviour and physiology of the resulting pups were then studied.dietary composition as important as number of caloriesthe scientists discovered that male mice fed low protein and high carbohydrate diets were more likely to have male offspring with higher levels of anxiety, as measured by time spent in the safety zones of their maze. they also found that male mice that were fed high fat diets were more likely to have daughters with higher levels of body fat and markers of metabolic disease.“our study shows that the type of diet eaten before conception can program specific characteristics of the next generation,” says co-senior author and leader of the gecko consortium professor romain barrès, from the university of copenhagen and université côte d’azur, nice.“it is extraordinary that by titrating mixtures of protein, fat and carbs in the father’s diet we could influence specific features of his sons and daughters health and behaviour. there is some important biology at play here,” said professor stephen simpson, co-senior author and academic director of the charles perkins centre at the university of sydney.the team also observed that males on a low protein diet also ate more food overall. however, thanks to the study design, they could determine that both the amount of calories, and the macronutrient composition of the males’ diets, influenced the health of their offspring.“our study shows that it’s not just eating too much or too little, but the composition of the diet that can have an impact on future children,” says professor romain barrès.the work was conducted in mice and has opened the way for the team to study the molecular mechanisms involved. the mouse work is part of a broader series of studies within the gecko consortium, involving humans and other mammals at partner institutions.“we think our study is a step towards establishing dietary guidelines for fathers to be, with the ultimate goal of lowering the risk of metabolic disease and mood disorders in the next generation,” says professor romain barrès.declaration: all study procedures were reviewed and approved by the university of sydney animal ethics committee (project number 2019/1610). this work was supported by a challenge programme grant from the novo nordisk foundation (nnf18oc0033754) to the gametic epigenetics consortium against obesity (gecko). the novo nordisk foundation center for basic metabolic research is an independent research center at the university of copenhagen, partially funded by an unrestricted donation from the novo nordisk foundation (nnf18cc0034900). this work was supported by the french government (national research agency, anr) through the “investments for the future” programs labex signalife anr-11-labx-0028-01 and idex ucajedi anr-15-idex-01. .
